Goat anti Mouse Disabled-1 (NT)Catalogue number: U100P
|Product Type||Polyclonal Antibody|
Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled Ð1 acts downstream of reelin in a signalling pathway.
Synonyms: Disabled homolog 1; DAB1
Goats were immunized with a recombinant protein corresponding to amino acids 1-179 of mouse disabled coupled to a GST fusion protein.
Product Form: Unconjugated
Formulation: Provided as 0.2ml sterile filtered solution in phosphate buffered saline with 0.08% sodium azide.
Purification Method: Ammonium Sulfate Precipitation
Concentration: See vial for concentration
Immunoblotting at 1-5 µg/ml, Immunoprecipitation at 5-10µg/ml. Optimal concentration should be evaluated by serial dilutions.
Functional Analysis: Western Blotting
Positive Control: 293 cells transfected with Dab-1 HA tag
Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles
Product Stability: See expiration date on vial
Shipping Conditions: Ship at ambient temperature, freeze upon arrival
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information.
1. Howell B.W. et.al (1997). EMBO Journal 1,121-132
2. Homayouni,R. et.al (1999) J. Neuroscience 19(17), 7505-7515
Database Name: UniProt
Accession number: P97318 (Mouse)
Species Accession: Mouse
Safety Datasheet(s) for this product:
/wp-content/uploads/SDS/Antibody SDS with Sodium AzideV2.pdf
Goat anti Mouse Disabled-1 (NT)
|Figure01 – Western blot analysis using Disabled-1 (NT) (Cat. No. U100P) (1) and (CT) (Cat. No. U105P) (2) on mouse brain extracts.|