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CD204, Macrophage Scavenger Receptor


Catalogue number: CD204-1

CloneSRA-E5
IsotypeIgG1
Product Type Primary Antibodies
Units50 µg
HostMouse
Species reactivity Human
Application IHC(C, P), WB
Background
The macrophage scavenger receptor (MSR-A) has been identified in the search for a receptor molecule responsible for the deposition of cholesterol in atherosclerosis by receptor-mediated uptake of LDL. MSR-A has a broad spectrum for ligand binding: oxidized LDL, acetylated LDL, advanced glycation end products (AGE), polyribonucleotides such as poly-G and poly-I, and bacterial surface lipids, lipopolysaccharides, and lipoteichoic acid. MSR-A, CD204, a 72 kDa glycoprotein from histiocytic macrophages.

Positive Control
Human Liver

Pre-Treatment
Formaldehyde-fixed tissue must be subjected to antigen unmasking, 10 min citrate buffer 0.01 M, pH 2.0, alternatively, glycol-based demasking solution G may be used (DE007).

Immunogen
Recombinant human protein type I SR-A

Working Concentration
(liquid conc.) 2 μg / ml

Secondary Reagents
As secondary system in immunohistochemistry we recommend our universal staining kits DAB and AEC (DA005 and AE005), the staining kit mouse IgG (rat absorbed, Item No. DA007)

Storage
-20°C

References
1.Takeya M., Tomokiyo R., Jinnouchi K., Sakaguchi H., et al: Macrophage Scavenger Receptors: Structure, Function and Tissue Distribution: Acta Histochem. Cytochem. 32 (1): 47 to 51.1999
2. Tomokiyo R., Jinnouchi K., Honda M., Wada Y., Hanada N., Hiraoka T., Suzuki H., Kodama T., Takahashi K., Takeya M .: Production, characterization, and interspecies reactivities of A macrophage scavenger receptor: Atherosclerosis, 2001
3.Takeya M., Tomokiyo R., Jinnouchi K. Honda M. et al: CD204: Macrophage scavenger receptor, a new differentiation marker for macrophages: part 9 Myeloid Cells, New CD Antigens, Leucocyte Typing Ⅶ, Oxford Univ. Press, 2001

Caution
This is a research reagent for in vitro studies. It is not intended for clinical diagnosis. Liability for improper use is excluded by the manufacturer.

Safety Datasheet(s) for this product:

CD204, Macrophage Scavenger Receptor

SKU: CD204-1 Categories: ,

Brand

Contact us

Exalpha Biologicals, Inc.
2 Shaker Road, Unit B101
Shirley, MA 01464
Phone: 978-425-1370
Email: info@exalpha.com

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