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Cathepsin D


Catalogue number: CA111

Units1 ml
HostRabbit
Application IHC(P)
Background
Beside other factors like EGFR and hormone receptors, Cathepsin D is thought to be a prognostic factor in mamma carcinoma. It is indicative for tumour progression and invasion. Cathepsin D is a lysosomal enzyme that is involved in intracellular protein metabolism. It is synthesized as a 54 kDa precursor which is processed to a 46 kDa active enzyme product. It is involved in the metabolism of proteoglycans, cartilage collagen and in bone resorption. Human Cathepsin D.

Positive Control
Breast carcinoma

Pre-Treatment
Pre-treatment with proteases is not recommended!

Immunogen
Recombinant human Cathepsin D

Purification Method
Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**. The volume is sufficient for at least 100 immunohistochemical tests (100 µl working solution / test). Use appropriate antibody diluent e.g. BIOLOGO Art. No. PU002.

Working Concentration
(liquid conc.) 1:10-1:50

Concentration
40 µg/ml

Incubation Time
60 min at RT

Secondary Reagents
We recommend the use of BIOLOGO's Universal Staining System DAB (Art. No. DA005) or AEC (Art. No. AE005).

Product
Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**. The volume is sufficient for at least 100 immunohistochemical tests (100 µl working solution / test). Use appropriate antibody diluent e.g. BIOLOGO Art. No. PU002.

Applications
IHC(P)

Cross Reactivity
Human

Storage
2-8°C

References
1. Garcia M., et al. (1987) Immunohistochemical distribution of the 52-kDa protein in mammary tumours: a marker associated with cell proliferation rather than with hormone responsiveness. J. Steroid Biochem. 27(1): 439.

Caution
*These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals. ** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!

Safety Datasheet(s) for this product:

Cathepsin D

$538.00

SKU: CA111 Categories: ,

Brand

Contact us

Exalpha Biologicals, Inc.
2 Shaker Road, Unit B101
Shirley, MA 01464
Phone: 978-425-1370
Email: info@exalpha.com

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