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Beta-Defensin-4 (MBD-4)

Catalogue number: MBD041-A

Units100 µg
HostRabbit
Application ELISA
IHC not established
RIA
Western Blotting

Background
Mammalian defensins are Cys-rich antimicrobial peptides which specifically react against Gram-negative bacteria. Originally defensins were isolated from hemolysates, but they can also be found on the cell surface of epithelia of the urogenital tract, lung, and trachea. In leukocytes defensins are stored in granules being released into phagolysosomes for the destruction of incorporated microorganisms. Amino acid sequences of alpha-defensins 1-4 (HNP1-4) and beta-Defensins 1-4 (HBD1-4 and MBD-4) are known.

Source

Immunogen: Synthetic peptide: 11 aa N-terminal sequence of MBD-4 coupled to KLH

Product
Antigen-agarose purified IgG in PBS, BSA, lyophilized without preservative. Reconstitute with 0.1 ml sterile water to get an antibody concentration of 1 mg/ml. Dilution buffers are depending on the type of application.

Purification Method: Antigen-agarose purified IgG in PBS, BSA, lyophilized without preservative. Reconstitute with 0.1 ml sterile water to get an antibody concentration of 1 mg/ml. Dilution buffers are depending on the type of application.

Specificity

Species Reactivity: Mouse

Applications
WB, ELISA, RIA, IHC not established

Working Concentration: (lyophilisate) 1-10 µg/ml Western Blot using ECL technique , 0.5-1 µg/ml ELISA,IHC 2-10 µg/ml (not tested)

Storage
-20°C

Caution
These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

References
1. Jia H.P., Wowk S.A., Schutte B.C., Lee S.K., Vivado A., Tack B.F., Bevins C.L., McCray P.B. Jr. A novel murine beta-defensin expressed in tongue, esophagus, and trachea. J. Biol. Chem. 275:33314-33320(2000) [PubMed] [Europe PMC] 2. Mural R.J., Adams M.D., Myers E.W., Smith H.O. et al. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science. 2002 May 31;296(5573):1661-71. 3. Robert A Dorschner, Kenneth H Lin, Masamoto Murakami and Richard L Gallo (2003) Neonatal Skin in Mice and Humans Expresses Increased Levels of Antimicrobial Peptides: Innate Immunity During Development of the Adaptive Response Pediatric Research 53, 566–572

Protein Reference(s)

Database Name: UniProt

Accession number: P82019 (DEFB4_MOUSE)

Species Accession: Mouse


Beta-Defensin-4 (MBD-4)

$855.00

SKU: MBD041-A Categories: ,

Brand

Contact us

Exalpha Biologicals, Inc.
2 Shaker Road, Unit B101
Shirley, MA 01464
Phone: 978-425-1370
Email: info@exalpha.com

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