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Beta-Defensin-3 (HBD-3/MBD-3) control peptide


Catalogue number: DEF03-P

Units100 µg
Application Control peptide for DEF03-A and DEF03-S antibodies
Background
Human defensins are Cys-rich antimicrobial peptides which specifically react against Gram-negative bacteria. Originally defensins were isolated from hemolysates, but they can also be found on the cell surface of epithelia of the urogenital tract, lung, and trachea. In leukocytes defensins are stored in granules being released into phagolysosomes for the destruction of incorporated micro-organisms. Amino acid sequences of alpha-defensins 1-4 (HNP1-4) and beta-Defensins 1-4 (HBD1-4) are known. Mature Human Beta-Defensin-3 (HBD-3) shares app. 22% aa sequence homology with HBD-1. Mixture of synthetic peptides 15 aa near C-terminus of the mature HBD-3 (LPKEEQIGKCSTRGR) and 13 aa of N-terminal MBD-3.

Purification Method
Synthetic peptide lyophilized from PBS pH 7.5 at 1 mg/ml

Working Concentration
(lyophilisate)

Product
Synthetic peptide lyophilized from PBS pH 7.5 at 1 mg/ml

Applications
Control peptide for DEF03-A and DEF03-S antibodies

Storage
-20'°C'

References
1. Harder J., Bartels J., Christophers E., and J.-M. Schröder (1997) Antibacterial peptide specific for Gram-negative Bacteria / also effective for Candida albicans. Nature 387; 861ff 2. Bals R., Wang X., Meegalla R. L., Wattler S., et al. (1999) Mouse ß-Defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs. Infection and Immunity 67(7); 3542-3547. 3. Jia H.P., Schutte B.C., Schudy A., Linzmeier R., et al. (2001) Discovery of new human beta-defensins using a genomics-based approach. Gene 263(1-2);211-218. 4. Garcia J.R., Jaumann F., Schulz S., Krause A., et al. (2001) Identification of a novel multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. Cell Tissue Res. 306(2); 257-264. 5. Harder J., Bartels J., Christophers E., and J.-M. Schröder (2001) Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J. Biol. Chem. 276(8); 5707-5713.

Caution
These products are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

Safety Datasheet(s) for this product:

Beta-Defensin-3 (HBD-3/MBD-3) control peptide

$348.00

SKU: DEF03-P Categories: ,