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Beta-Defensin-2 (HBD-2)


Catalogue number: DEF002

Units50 µl
HostRabbit
Application ELISA
IHC(C
P)
RIA
Background
Human defensins are Cys-rich antimicrobial peptides which specifically react against Gram-negative bacteria. Originally defensins were isolated from hemolysates, but they can also be found on the cell surface of epithelia of the urogenital tract, lung, and trachea. In leukocytes defensins are stored in granules being released into phagolysosomes for the destruction of incorporated microorganisms. Amino acid sequences of alpha-defensins 1-4 (HNP1-4) and beta-Defensins 1-4 (HBD1-4) are known. Beta-defensin-1 and beta-defensin-2 share 34% amino acid sequence homology. ß-Defensin-2 (human) hBD-2, no cross-reactivity with human beta-defensin-1 and human alpha-defensin-1 in dir. ELISA using 0,5 µg/well.

Positive Control
Skin or oral mucosa

Immunogen
Synthetic human-ß-Defensin-2 conjugated to bovine thyroglobulin, hBD-2: Gly-Ile-Gly-Asp-Pro-Val-Thr-Cys-Leu-Lys-Ser-Gly-Ala-Ile-Cys-His-Pro-Val-Phe-Cys-Pro-Arg-Arg-Tyr-Lys-Gln-Ile-Gly-Thr-Cys-Gly-Leu-Pro-Gly-Thr-Lys-Cys-Cys-Lys-Lys-Pro (MW 4328,2)

Purification Method
Antiserum lyophilised from 1 mM phosphate buffer (pH 7.0)

Working Concentration
(lyophilisate) 1:5000 - 1:100000 dir. ELISA

Product
Antiserum lyophilised from 1 mM phosphate buffer (pH 7.0)

Applications
IHC(C, P), ELISA, RIA

Cross Reactivity
Human

Storage
-20'°C'

References
1. Harder J., Bartels J., Christophers E., and J.-M. Schröder (1997) Antibacterial peptide specific for Gram-negative Bacteria / also effective for Candida albicans. Nature 387; 861ff 2. Hiratsuka T., Nakazato M., Date Y., Ashitani J., Minematsu T, Chino N., and S. Matsukura (1998) Biochem. Biophys. Res. Comm. (Pharmacol.) 249; 943 ff

Caution
These antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

Safety Datasheet(s) for this product:

Beta-Defensin-2 (HBD-2)

$1,170.00

SKU: DEF002 Categories: ,

Brand

Contact us

Exalpha Biologicals, Inc.
2 Shaker Road, Unit B101
Shirley, MA 01464
Phone: 978-425-1370
Email: info@exalpha.com

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