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Beta-Defensin-2 (HBD-2) Control Peptide


Catalogue number: DEF002-P

Units100 µg
Application Control peptide
Background
Human defensins are Cys-rich antimicrobial peptides which specifically react against Gram-negative bacteria. Originally defensins were isolated from hemolysates, but they can also be found on the cell surface of epithelia of the urogenital tract, lung, and trachea. In leukocytes defensins are stored in granules being released into phagolysosomes for the destruction of incorporated microorganisms. Amino acid sequences of alpha-defensins 1-4 (HNP1-4) and beta-Defensins 1-4 (HBD1-4) are known. Beta-defensin-1 and beta-defensin-2 share 34% amino acid sequence homology. Synthetic Human-ß-Defensin-2 (hBD-2): Gly-Ile-Gly-Asp-Pro-Val-Thr-Cys-Leu-Lys-Ser-Gly-Ala-Ile-Cys-His-Pro-Val-Phe-Cys-Pro-Arg-Arg-Tyr-Lys-Gln-Ile-Gly-Thr-Cys-Gly-Leu-Pro-Gly-Thr-Lys-Cys-Cys-Lys-Lys-Pro (MW 4328,2).

Purification Method
Synthetic peptide lyophilized from acetic acid

Working Concentration
(lyophilisate)

Product
Synthetic peptide lyophilized from acetic acid

Applications
Control peptide

Storage
-20'°C'

References
1. Harder J., Bartels J., Christophers E., and J.-M. Schröder (1997) Antibacterial peptide specific for Gram-negative Bacteria / also effective for Candida albicans. Nature 387; 861ff 2. Hiratsuka T., Nakazato M., Date Y., Ashitani J., Minematsu T, Chino N., and S. Matsukura (1998) Biochem. Biophys. Res. Comm. (Pharmacol.) 249; 943 ff 3. Hoover D.M., Rajashankar K.R., Blumenthal R., Puri A., Oppenheimer J.J., Chertov O., and Lubkowski J. (2000) The structure of human beta-defensin-2 shows evidence of higher order oligomerization. J Biol Chem. 275(42):32911-8 4. Hiratsuka T, Mukae H, Iiboshi H, Ashitani J, Nabeshima K, Minematsu T, Chino N, Ihi T, Kohno S, Nakazato M (2003) Increased concentrations of human beta-defensins in plasma and bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis.Thorax. 58(5):425-30.

Caution
These products are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

Beta-Defensin-2 (HBD-2) Control Peptide

$664.00

SKU: DEF002-P Categories: ,