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Rabbit anti Human Amyloid Precursor Protein (APP) (CT)

Catalogue number: X1134P

Alzheimer disease amyloid protein, ABPP. APPI, PreA4, Cerebral vascular amyloid peptide

Product Type Polyclonal Antibody
Units100 µg
Species reactivity Human
Application Western Blot
Product Form

Accumulation of the amyloid- peptide (A ) in the cerebral cortex is a critical event in the pathogenesis of AlzheimerÕs disease. The amyloid protein precursor (APP) is cleaved by secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for secretase to generate the 4 kDa amyloid- peptide (A ), which is deposited in the brains of all suffers of AlzheimerÕs disease.

Positive Control
Murine brain lysate

Synthetic peptide corresponding to amino acids 737 to 751 of human amyloid A4 protein precursor (APP) or 85 to 99 of the C99 generated by secretases. This sequence is identical to those of monkey, mouse, rat, chicken and a variety of other species.

Purification Method
Antigen Immunoaffiinity Purification

See vial for concentration

Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative

Functional Analysis
Western Blotting

Detects APP and C99 fragment by Western blot at 0.5 to 1 µg/ml. Detects an approximately 120 kDa band in human, mouse and rat brain tissue lysates. Optimal concentration should be evaluated by serial dilutions.

Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles

Ship Conditions
Ship at ambient temperature, freeze upon arrival

Product Stability
Products are stable for one year from purchase when stored properly

1. Ponte, P., et al. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 1988, 331, 525-527. 2. Selkoe, D.J. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell Biol. 1994, 10, 373-403

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

Safety Datasheet(s) for this product:

Sodium Azide

Rabbit anti Human Amyloid Precursor Protein (APP) (CT)



Contact us

Exalpha Biologicals, Inc.
2 Shaker Road, Unit B101
Shirley, MA 01464
Phone: 978-425-1370