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Rabbit anti Human Amyloid (Abeta) (N-terminal)


Catalogue number: X1884P

Synonyms
APP, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, Protease nexin-II, PN-II, APPI, PreA4

IsotypeIgG
Product Type Antigen Immunoaffinity Purified Polyclonal
Units50 µg
HostRabbit
Species reactivity Human
Application Dot Blot
Enzyme Immunoassay
Radio Immunoassay
Product Form
Unconjugated

Background
Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity.

Positive Control
No cross-reactivity against a negative spanning region of Aβ has been observed by ELISA.

Immunogen
Synthetic peptide derived from the N-terminal region of the amyloid beta peptide.

Purification Method
Purified from rabbit serum by epitope-specific affinity chromatography.

Concentration
See vial for concentration

Formulation
Purified IgG in phosphate buffered saline, pH 7.4

Functional Analysis
ELISA

Applications
For dot blot applications, we recommend using the antibody at 1.0 µg/mL.Optimal concentration should be evaluated by serial dilutions.

Storage
Product should be stored at -70ºC. Aliquot to avoid freeze/thaw cycles

Ship Conditions
Ship on dry ice, freeze upon arrival

Product Stability
Products are stable for one year from purchase when stored properly

References
1. Head, E., Moffat, K., Das, P., Sarsoza, F., Poon, W.W., Landsberg, G., Cotman, C.W., Murphy, M.P. (2005) β-Amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiol Aging. 26(5): 749-763. 2. Borchelt, D.R. et al. (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19:939-945. 3. Savage, M.J. et al. (1998) Turnover of amyloid β-protein in mouse brain and acute reduction of its level by phorbol ester. J. Neurosci. 18:1743-1752.

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.

Safety Datasheet(s) for this product:

Rabbit anti Human Amyloid (Abeta) (N-terminal)

$698.00