Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery

Armenian Hamster anti CD27

  • Product Code: MUB0365P
  • Size: .1 mg
  • Price (USD): $310

Product Code

MUB0365P		 Quantity:      

Product Name

Armenian Hamster anti CD27

Size

.1 mg

Price (USD)

$310

Background

Members of the tumor necrosis factor receptor (TNFR) family are emerging as important molecules impliCated in the regulation of prolifeRation, differentiation and survival of T and B lymphocytes. Among these receptors is CD27, the function of which has thus far only been studied in the Human system, where it amplifies the T cell prolifeRative response induced by TCR triggering. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for geneRation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-_B and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a pro-apoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.

Host

Armenian Hamster

Isotype

IgG

Species Reactivity

Human,Mouse

Product Usage

LG.3A10 and LG.8A6 see a different epitope. A combination can therefore be developed into a double determinant ELISA to detect soluble Mouse CD27. LG.3A10 cross-react with Human CD27, LG.8A6 does not.

Product Type

Primary Antibodies

Applications

ELISA,Flow Cytometry,Immunohistochemistry (frozen),Immunohistochemistry (paraffin),Immunoprecipitation

Fields of Interest

Cell adhesion,Immunology

Product Source

mAbs to murine CD27 were geneRated injecting a mixture of the mCD27tag expresssing clones AR0524 and AR0530; Hamster spleen cells and SP2/0 murine myeloma cells were fused.

Product Formulation

Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.

Storage Conditions

Store at 4