The Edg family of G-Protein Coupled Receptors

The endothelial cell differentiation gene (Edg) family of G-protein coupled receptors (GPCR) function as receptors for Lysophosphatidic acid (LPA) and structurally related sphingosine-1-phosphate (S1P). LPA and S1P are predominantly released by activated platelets and are present in blood plasma and serum, mainly bound to albumin and lipoprotein. Both LPA and S1P mediate similar biological cell responses including cell proliferation, migration, … Read More

BrdU

BrdU 5′-bromo-2′-deoxyuridine (BrdU) is a synthetic analogue of the nucleoside thymidine, in which the 5-methyl group is substituted by bromine. It is commonly used for the detection of proliferating cells via its incorporation into newly synthesized DNA; replicating cells can subsequently be identified through the use of anti-BrdU antibodies. BrdU has been used for decades and has extremely wide utility. … Read More

CRISPR reveals genetic master switches behind butterfly wing patterns

Recent work by Rachael Lallensack published in Nature, 18 September 2017 has shed light on the way in which the intricate patterns on butterfly wings form. It had been thought that the process of generating the beautiful and complex patterns on butterfly wings might be due to the action of a multitude of different genes. Recent studies, however, seem to … Read More