M13 Bacteriophage

M13 Bacteriophage Background Discovered in 1963, M13 bacteriophage was first isolated from Escherichia coli bacteria. M13 is a single stranded DNA virus that belongs to the Inoviridae family of filamentous bacteriophages, which infect gram- negative bacteria. It is a member of the Ff (F-specific filamentous phage) class of phages and is one of the smallest filamentous bacteriophages known. M13 phage … Read More

High quality reagents for Edg research

High quality reagents for Edg research The Edg GPCRs have been extensively studied due to the role which they play in the regulation of fundamental cellular processes including proliferation, migration and differentiation. Such research is dependent on the use of high quality reagents, and Exalpha Biologicals offers a comprehensive range of antibodies (monoclonal and polyclonal), blocking peptides, membrane preparations and … Read More

The Edg family of G-Protein Coupled Receptors

The endothelial cell differentiation gene (Edg) family of G-protein coupled receptors (GPCR) function as receptors for Lysophosphatidic acid (LPA) and structurally related sphingosine-1-phosphate (S1P). LPA and S1P are predominantly released by activated platelets and are present in blood plasma and serum, mainly bound to albumin and lipoprotein. Both LPA and S1P mediate similar biological cell responses including cell proliferation, migration, … Read More

BrdU

BrdU 5′-bromo-2′-deoxyuridine (BrdU) is a synthetic analogue of the nucleoside thymidine, in which the 5-methyl group is substituted by bromine. It is commonly used for the detection of proliferating cells via its incorporation into newly synthesized DNA; replicating cells can subsequently be identified through the use of anti-BrdU antibodies. BrdU has been used for decades and has extremely wide utility. … Read More

CRISPR reveals genetic master switches behind butterfly wing patterns

Recent work by Rachael Lallensack published in Nature, 18 September 2017 has shed light on the way in which the intricate patterns on butterfly wings form. It had been thought that the process of generating the beautiful and complex patterns on butterfly wings might be due to the action of a multitude of different genes. Recent studies, however, seem to … Read More