Available in bulk quantities, get our new clone HEA125 against EpCAM: MUB2061P

The popular human epithelial cell marker antibody is specific for a 34 kDa epithelium-specific membrane glycoprotein. It labels the majority epithelial cells and epithelium derived tumours, reacting strongly with all carcinoma derived from the intestinal tract, stomach, pancreas, breast, lung, kidney, prostate, ovary and thyroid gland (1). The ability of HEA125 to distinguish between carcinoma and non-carcinoma has significant clinical … Read More

Research news: FIX&PERM® used in a multiparameter flow cytometric assay to advance knowledge on haematological malignancies

A strategy combining the use of FIX&PERM® for intracellular detection of Ki-67 and 10 colour flow cytometry of cell surface markers was used to determine reference values for the proliferative activity of hematopoietic cells in the bone marrow. Hematologic malignancies such as leukaemia and lymphomas are forms of cancer that begin in the cells of blood-forming tissues like the bone … Read More

Eggcellent Antibodies

Eggcellent Antibodies   Utilising Gallus’ eggspertise, Exalpha Biologicals is now able to offer a greatly expanded range of antibodies generated in chicken.   Why use chickens to produce antibodies?   Polyclonal antibodies generated in chickens, offer many advantages over polyclonal antibodies traditionally produced in mammals such as rabbits, goats and sheep. Chickens (Gallus domesticus) produce immunoglobulin not only in their … Read More

Exalpha Biologicals Announces Acquisition Gallus Immunotech Inc.

Exalpha Biologicals, Inc. Announces Acquisition of Leading Producer of Egg-Derived Antibodies Gallus Immunotech Inc. Continues expansion of its range of Antibodies and Reagents that answer real needs   Shirley, Massachusetts, USA – June 6th, 2018 – Exalpha Biologicals, Inc., founded over 20 years ago and dedicated to accelerating the pace of discovery in the life science arena announces the acquisition … Read More

Clinical IHC Markers

Clinical IHC Markers Immunohistochemistry (IHC) is a technique which is used to study the tissue distribution of a defined target. It relies on antibodies to detect specific proteins in a sample of tissue which has been paraffin embedded or frozen and can provide a wealth of data regarding protein localization and relative levels of expression. In a clinical laboratory setting … Read More

Veterinary Antibodies

Veterinary Antibodies Veterinary research is essential to understanding a wide range of pathological conditions in veterinary species. The research undertaken supports a broad range of veterinary disciplines including clinical veterinary medicine, animal husbandry, infectious disease dynamics, zoonotics and comparative medicine. In addition, many diseases affecting companion animals, livestock, wild animals and birds have an impact on global economics, and ongoing … Read More

The Edg Family of G-Protein Coupled Receptors

What are GPCRs? G-Protein Coupled Receptors (GPCRs) represent the largest and most diverse family of transmembrane receptors in the human genome, and have been extensively targeted by the pharmaceutical industry in the development of therapeutics. They are involved in a huge array of functions and, as their name suggests, interact with G-proteins (specialized proteins capable of binding GTP and GDP) … Read More

SPARC

Background Secreted Protein Acid Rich in Cysteine (SPARC), also known as ON (osteonectin) and BM-40 (basement-membrane protein 40), is a prototypic member of the SPARC family of proteins, a diverse group of proteins that each have an acidic domain, a follistatin-like domain and an extracellular calcium binding E-F hand motif. SPARC is a 34-35kD non-structural matricellular protein that is primarily … Read More

Link between p34(cdc2) and Punctate Palmoplantar Keratoderma.

Link between p34(cdc2) and Punctate Palmoplantar Keratoderma. p34(cdc2) is a kinase which is an essential nuclear protein for mitosis in human cells. During the prophase/metaphase transition the inactive phosphorylated form of p34(cdc2) is dephosphorylated to yield the active form of the protein.  Recent data published in Nature Genetics (14 October 2012) from Pohler et al link a heterozygous loss-of-function mutation … Read More

MUB1501P – a well-characterized antibody against p53

Although only a fraction of genes in the human genome have a direct association with the induction and development of cancer, two broad gene classes – proto-oncogenes and tumor suppressor genes – have demonstrated a clear link to progression of the disease. These genes encode various proteins involved in regulating cell growth and proliferation, and while gain-of-function mutations in proto-oncogenes … Read More