Exalpha Biologicals Announces Acquisition Gallus Immunotech Inc.

Exalpha Biologicals, Inc. Announces Acquisition of Leading Producer of Egg-Derived Antibodies Gallus Immunotech Inc. Continues expansion of its range of Antibodies and Reagents that answer real needs   Shirley, Massachusetts, USA – June 6th, 2018 – Exalpha Biologicals, Inc., founded over 20 years ago and dedicated to accelerating the pace of discovery in the life science arena announces the acquisition … Read More

Clinical IHC Markers

Clinical IHC Markers Immunohistochemistry (IHC) is a technique which is used to study the tissue distribution of a defined target. It relies on antibodies to detect specific proteins in a sample of tissue which has been paraffin embedded or frozen and can provide a wealth of data regarding protein localization and relative levels of expression. In a clinical laboratory setting … Read More

Veterinary Antibodies

Veterinary Antibodies Veterinary research is essential to understanding a wide range of pathological conditions in veterinary species. The research undertaken supports a broad range of veterinary disciplines including clinical veterinary medicine, animal husbandry, infectious disease dynamics, zoonotics and comparative medicine. In addition, many diseases affecting companion animals, livestock, wild animals and birds have an impact on global economics, and ongoing … Read More

The Edg Family of G-Protein Coupled Receptors

What are GPCRs? G-Protein Coupled Receptors (GPCRs) represent the largest and most diverse family of transmembrane receptors in the human genome, and have been extensively targeted by the pharmaceutical industry in the development of therapeutics. They are involved in a huge array of functions and, as their name suggests, interact with G-proteins (specialized proteins capable of binding GTP and GDP) … Read More

SPARC

Background Secreted Protein Acid Rich in Cysteine (SPARC), also known as ON (osteonectin) and BM-40 (basement-membrane protein 40), is a prototypic member of the SPARC family of proteins, a diverse group of proteins that each have an acidic domain, a follistatin-like domain and an extracellular calcium binding E-F hand motif. SPARC is a 34-35kD non-structural matricellular protein that is primarily … Read More

Link between p34(cdc2) and Punctate Palmoplantar Keratoderma.

Link between p34(cdc2) and Punctate Palmoplantar Keratoderma. p34(cdc2) is a kinase which is an essential nuclear protein for mitosis in human cells. During the prophase/metaphase transition the inactive phosphorylated form of p34(cdc2) is dephosphorylated to yield the active form of the protein.  Recent data published in Nature Genetics (14 October 2012) from Pohler et al link a heterozygous loss-of-function mutation … Read More

MUB1501P – a well-characterized antibody against p53

Although only a fraction of genes in the human genome have a direct association with the induction and development of cancer, two broad gene classes – proto-oncogenes and tumor suppressor genes – have demonstrated a clear link to progression of the disease. These genes encode various proteins involved in regulating cell growth and proliferation, and while gain-of-function mutations in proto-oncogenes … Read More

M13 Bacteriophage

M13 Bacteriophage Background Discovered in 1963, M13 bacteriophage was first isolated from Escherichia coli bacteria. M13 is a single stranded DNA virus that belongs to the Inoviridae family of filamentous bacteriophages, which infect gram- negative bacteria. It is a member of the Ff (F-specific filamentous phage) class of phages and is one of the smallest filamentous bacteriophages known. M13 phage … Read More

High quality reagents for Edg research

High quality reagents for Edg research The Edg GPCRs have been extensively studied due to the role which they play in the regulation of fundamental cellular processes including proliferation, migration and differentiation. Such research is dependent on the use of high quality reagents, and Exalpha Biologicals offers a comprehensive range of antibodies (monoclonal and polyclonal), blocking peptides, membrane preparations and … Read More

The Edg family of G-Protein Coupled Receptors

The endothelial cell differentiation gene (Edg) family of G-protein coupled receptors (GPCR) function as receptors for Lysophosphatidic acid (LPA) and structurally related sphingosine-1-phosphate (S1P). LPA and S1P are predominantly released by activated platelets and are present in blood plasma and serum, mainly bound to albumin and lipoprotein. Both LPA and S1P mediate similar biological cell responses including cell proliferation, migration, … Read More