Exalpha Biologicals, Inc.

Accelerating the Pace of Discovery

Product Highlight

FIX&PERM Cell Fixation and Permeabilization Kit

Flow cytometric analyses with monoclonal antibodies were so far mainly restricted to cell surface molecules. Intracellular structures such as cytoplasmic or nuclear enzymes, oncoproteins, cytokines, immunoglobulins etc. were largely excluded from such studies. Also excluded from flow cytometric studies were cytoplasmic localizations of well-established membrane molecules like CD3 and CD22, which, in their cytoplasmic form, are the most reliable lineage markers in undifferentiated leukemia. With the FIX&PERM® Kit flow cytometric analysis of intracellular antigens has become as easy as surface antigen studies. The only prerequisite is the availability of suitable antibody conjugates. Most of the available monoclonal antibody conjugates can be used with the FIX&PERM® Kit, some determinants are sensitive, however, to the fixation step involved. This and the optimal fixation time have to be tested for each reagent.

News

Two more of our excellent products have been published by PubMed:

Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis
Using Exalpha SPARC Antibody (Cat. No. X1867P)

Molecular mechanism underlying the pharmacological interactions of the protein kinase C-β inhibitor enzastaurin and erlotinib in non-small cell lung cancer cells
Using Exalpha's FITC labeled anti PY20 Antibody (Cat. No. X1017)

Clinical IHC Markers

Cat # Target - Clone Name Size Oncology Area
T110M Alx-4 Monoclonal Antibody 100 µg Bladder, Colon
X1726M alpha T-Catenin Monoclonal Antibody 100 µg Bladder
0561 CD56 Monoclonal Antibody 250 µg Multiple
0561s CD56 Monoclonal Antibody 25 µg Multiple
0561P CD56 Prediluted Monoclonal Antibody 7 ml Multiple
X1733M Cytokeratin 10 Monoclonal Antibody 100 µg HCC, SCC
X1734M Cytokeratin 10 Monoclonal Antibody 100 µg HCC, SCC
X1735M Cytokeratin 13 Monoclonal Antibody 100 µg SCC
X1736M Cytokeratin 17 Monoclonal Antibody 100 µg SCC
X1729M Cytokeratin 4 Monoclonal Antibody 100 µg Oral Papiloma
X1730M Cytokeratin 7 Monoclonal Antibody 100 µg Multiple
X1731M Cytokeratin 7 Monoclonal Antibody 100 µg Multiple
X1732M Cytokeratin 8 Monoclonal Antibody 100 µg Breast, HCC, Lung
X1265M Dihydrodiol Dehydrogenase Monoclonal Antibody 100 µl Lung, SCC, Ovarian
X1355M ERCC1 Monoclonal Antibody 100 µg Multiple
X1262M Estrogen Receptor Monoclonal Antibody 100 µg Breast tumor
X1266M Estrogen Receptor Monoclonal Antibody 100 µg Breast tumor
X1567M Estrogen Receptor Monoclonal Antibody 100 µg Breast tumor
X2754P Histone H2A.x (S140) Antigen Immunoaffinity Purified Polyclonal 100 µg Renal Cancer, broad range of expression in other cancers.
X1260M Pan Keratin (4,5,6,8,10,13,18) Monoclonal Antibody 100 µg Multiple
X1390M Ku (p70) Monoclonal Antibody 100 µg Multiple
X1395M LRP/MVP (Drug Resistance Marker) Monoclonal Antibody 100 µg Multiple
X2053M Matrix Metalloproteinase 1 (MMP1) Monoclonal Antibody 200 µg Multiple
X2054M Matrix Metalloproteinase 2 (MMP2) Monoclonal Antibody 200 µg Multiple
X2055M Matrix Metalloproteinase 3 (MMP3) Monoclonal Antibody 200 µg Multiple
X2056M Matrix Metalloproteinase 9 (MMP9) Monoclonal Antibody 200 µg
X2057M Active Matrix Metalloproteinase 9 (MMP9) Monoclonal Antibody 200 µg Breast, Lung, Pancreas, Colon
X1405M Microphthalmia Transcription Factor (MiTF) Monoclonal Antibody 100 µg Bladder
X1406M Mismatch Repair Protein 2 (MSH2) Monoclonal Antibody 500 µl Multiple
n110m c-myc Monoclonal Antibody 100 µg Multiple
n115m c-myc Monoclonal Antibody 100 µg Multiple
X1414M MyoD1 Monoclonal Antibody 100 µg
X1856P Notum Polyclonal Antibody 100 µg HCC
X1493M p53 (a.a. 371-380) Monoclonal Antibody 100 µg Multiple
X1155P PIG3 (p53 inducible gene 3) Polyclonal Antibody 100 µg DNA Damage
X1156M PIG3 (p53 inducible gene 3) Monoclonal Antibody 100 µg DNA Damage
X1437M Progesterone receptor Monoclonal Antibody 100 µg Breast tumor
X1860P SPARC Polyclonal Antibody 100 µg HCC
X1867P SPARC Antigen Immunoaffinity Purified Polyclonal 70 µg HCC
X1858P Sulf2 Polyclonal Antibody 100 µg HCC
X1865P Sulf2 Antigen Immunoaffinity Purified Polyclonal 50 µg HCC
X1072M TCF-1 Monoclonal Antibody 100 µg Multiple
X1070M TCF-4 Monoclonal Antibody 100 µg Multiple
X1261M Tenascin Monoclonal Antibody 100 µg Multiple
X2058M Tissue Inhibitor of Matrix Metalloproteinase 1 (TIMP-1) Monoclonal Antibody 200 µg Multiple
X2061M Tissue Inhibitor of Matrix Metalloproteinase 2 (TIMP2) Monoclonal Antibody 200 µg Multiple
X1481M XRCC1 (X-Ray Repair Cross Complementing 1 Protein) Monoclonal Antibody 100 µg DNA Damage