Exalpha Biologicals, Inc.

Articles

Pohler, E., et al."Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma" Nature Genetics (2012), epub

p34(cdc2) Monoclonal Antibody, Clone POH-1 (Cat. # X1236M)

Immunohistochemical staining of formalin-fixed paraffin-embedded human small intestine tissue after heat induced antigen retrival. p34(cdc2) antibody (Cat. No. X1236M) used at 10 µg/ml.

Link between p34(cdc2) and Punctate Palmoplantar Keratoderma.

p34(cdc2) is a kinase which is an essential nuclear protein for mitosis in human cells. During the prophase/metaphase transition the inactive phosphorylated form of p34(cdc2) is dephosphorylated to yield the active form of the protein.  Recent data published in Nature Genetics (14 October 2012) from Pohler et al link a heterozygous loss-of-function mutation to clinical manifestations of punctate palmoplantar keratoderma. Knockdown of the alpha- and gamma-adaptin-binding protein p34 gene (AAGAB) in keratinocytes led to an increase in cell division and elevated levels of EGFR expression and tyrosine kinase phosphorylation. It therefore seems likely that p34 plays a key role in the hyper-proliferation of cells in this disorder.

p34(cdc2) and Related Cell Cycle Products
Cat. No.NameProduct TypeSize
X1236Mp34(cdc2)Monoclonal Antibody100 µg
X1327K1Bromodeoxyuridine (BrdU) Cell Proliferation AssayAssay Kit200 tests
X1327K2Bromodeoxyuridine (BrdU) Cell Proliferation AssayAssay Kit1000 tests
X1327K3Bromodeoxyuridine (BrdU) Cell Proliferation AssayAssay Kit5000 tests
X1623K1Bromodeoxyuridine (BrdU) Cell Proliferation AssayChemiluminescent Assay Kit200 tests
X1623K2Bromodeoxyuridine (BrdU) Cell Proliferation AssayChemiluminescent Assay Kit1000 tests
X1623K3Bromodeoxyuridine (BrdU) Cell Proliferation AssayChemiluminescent Assay Kit5000 tests
X1545KBromodeoxyuridine (BrdU) Immunohistochemical DetectionAssay Kit50 tests
X2044K1ApoMark Apoptosis DetectionAssay Kit30 tests
X2044K2ApoMark Apoptosis DetectionAssay Kit30 tests
C105MCDC25AMonoclonal Antibody100 µg
C110Mp15-ink4bMonoclonal Antibody100 µg
C115MCyclin EMonoclonal Antibody100 µg
C125MCyclin D1Monoclonal Antibody100 µg
C130MCyclin D2Monoclonal Antibody100 µg
C135MCyclin D3Monoclonal Antibody100 µg
C140MCyclin Dependent Kinase 4Monoclonal Antibody100 µg
C145MCyclin Dependent Kinase 7Monoclonal Antibody100 µg
C150MCyclin Dependent Kinase 6Monoclonal Antibody100 µg
C155Mp27kip1Monoclonal Antibody100 µg
C160Mp21 WAF-1Monoclonal Antibody100 µg
C165Mp19-ink4dMonoclonal Antibody100 µg
C170Mp16-ink4aMonoclonal Antibody100 µg
X1158Mp21 WAF-1Monoclonal Antibody100 µg
X1184MCyclin AMonoclonal Antibody100 µg
X1216PCyclin Dependent Kinase 4Polyclonal Antibody100 µg
X1541PPhospho-Cyclin Dependent Kinase 2Polyclonal Antibody100 µg
X1727MNPDC-1Monoclonal Antibody100 µg