Exalpha Biologicals, Inc.

References

1. Andrusiak, M.G., et al. "The Retinoblastoma Protein Is Essential for Survival of Postmitotic Neurons" J. Neurosci. (2012), 32, 14809-14814

2. Nizzari, M., et al. "Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling" J. Toxicol. (2012), online

3. Herrup, K., et al. "Divide and Die: Cell Cycle Events as Triggers of Nerve Cell Death" J. Neurosci. (2004), 24, 9232-9239

BrdU IHC Staining (Cat. # X1545K)

Immunohistochemical staining of mouse intestine from mouse injected with BrdU using Exalpha's BrdU IHC Kit (X1545K)

The Retinoblastoma Protein Is Essential for Survival of Postmitotic Neurons

Andrusiak et al [1] have recently made the observation that Rb is required for continued cell growth and survival in terminally differentiated neurons. There is mounting evidence from myriad sources that abnormal cell cycle signals can play a part in neuronal death [2, 3]. It has been difficult to elucidate the the role of Rb in context of neuronal cell death. Andrusiak et al used a murine Rb knockout mouse model to study the effects of Rb in vivo and in vitro. Their observations are published in the most recent issue of the J. of Neuroscience.

Exalpha has a broad range of reagents and kit for studying Rb and cell cycle events.

Retinoblastoma Products
Cat. No.NameProduct TypeSize
N120MRetinoblastoma, clone XZ104Monoclonal Antibody100 µg
N125MRetinoblastoma, clone XZ133Monoclonal Antibody100 µg
N130MRetinoblastoma, clone C36Monoclonal Antibody100 µg
N135MRetinoblastoma, clone XZ91Monoclonal Antibody100 µg
N140MRetinoblastoma, clone XZ55Monoclonal Antibody100 µg

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