Exalpha Biologicals, Inc.

Latest References

Pal, A., et al. "PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity." N Engl J Med 2012, 367, 1002-1011

PTEN and Obesity

PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity

There is considerable evidence that type 2 diabetes, obesity, and cancer are linked. The current study by Aparna et al demonstrates a link between mutations in the PTEN (tumor-suppressor phosphatase and tensin homologue or PTEN) insulin sensitivity and obesity. They conclude that PTEN haploinsufficiency is a monogenic cause of constitutive insulin sensitization that is obesogenic. They further demonstrate an apparent divergent effect of PTEN mutations where there are increased risks of obesity and cancer but also a decreased risk of type 2 diabetes via enhanced insulin sensitivity. This new evidence provides new insight into the role of PTEN in obesity and insulin sensitivity thereby inviting approaches for the development of potential treatments.

Cat. No.NameProduct TypeSize
D100PPTENSheep Polyclonal250 µg
X1844KAKT ELISA KitELISA KitOne 96-well plate
X1889MAKT, Clone 9Q7Monoclonal Antibody100 µg
X1890MPan AKTAntigen Affinity Purified Polyclonal200 µl
X2010MAKT/PKB [pS473]Phosphospecific Monoclonal10 miniblots
X2011PAKT/PKB [pT308]Phosphospecific Polyclonal10 miniblots