The popular human epithelial cell marker antibody is specific for a 34 kDa epithelium-specific membrane glycoprotein. It labels the majority epithelial cells and epithelium derived tumours, reacting strongly with all carcinoma derived from the intestinal tract, stomach, pancreas, breast, lung, kidney, prostate, ovary and thyroid gland (1).
The ability of HEA125 to distinguish between carcinoma and non-carcinoma has significant clinical applications. Used to distinguish different types of cancers, a recent paper by Haninger et al, includes HEA125 as part of a panel to differentiate between hepatoid adenocarcinoma of lung and hepatocellular carcinoma metastatic to lung (2).
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(1) Moldenhauer, G. et al, (1987) Epithelium-specific surface glycoprotein of Mr 34,000 is a widely distributed human carcinoma marker. Br. J. Cancer. 56: 714-721. PMID:2449234.
(2) Haninger, D.M. el al, (2014) Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature. Mod Pathol. 27 (4): 535-42. PMID:24030743