![]()
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
|
|
• Calcium Homeostasis Modulator Protein 1 (CALHM1) (Cat. No. X2410P) - Recently identified gene linked to Alzheimer's disease. CALHM1 encodes a multipass transmembrane glycoprotein that controls cystolic CA(2+) concentrations and Abeta levels. See new article in Cell. Dreses-Werringloer, U., et la. "A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Ab Levels, and Alzheimer’s Disease Risk." Cell 20008, 133, 1149-1161 • Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) - Protein which binds to the EGF-A domain of the low density lipoprotein receptor (LDLR) and signals LDLR degradation. This results in decreased LDL metabolism leading to hypercholesterolemia. Two antibodies available, one targeting a function blocking epitope (Cat. No. X2404P) and one which targets a non-blocking epitope (Cat. No. X2403P) • Antibodies to Microphthalmia - clones C5 and D5 - Both clones available alone or together in a cocktail for immunohistochemistry. Both suitable for IHC and detect human microphthalmia protein. • Monoclonal Luciferase antibody, clone Luci17 (Cat. No. X1171M) - An exceptional antibody at a great price….Useful to identify the Luciferase protein used as a reporter for gene expression studies. Made to Firefly Luciferase. Works in Western Blot, and IHC. (100µg - $210) Call for multiple vial/bulk pricing New Product • Sheep anti-human Glypican-3 (GPC3) (Cat. No. X2395P) - Sheep polyclonal antibody to the human GPC3 protein. Antibody recognizes the C-terminal of the GPC3 protein and with an epitope which does not overlap with the 1G12 anti-GPC3 monoclonal currently available on the market. Click link above for product specific page. BrdU Proliferation Assays/Kits Assay Kits • ApoMark™ DNA Fragmentation Apoptosis Detection Kit Lipid Signaling Family of Products Including antibodies to: Also, Active Recombinant Enzymes: Flow Cytometry/CD antibodies • CD 56 - the superior CD56 available today. Neurobiology Product Lines Including antibodies to: Wnt Pathway Antibodies including….
|
UPCOMING MEETINGS Exalpha will be sponsoring the Glycolipid and Sphingolipid Biology Conference, Feb. 7-12, 2010, in Ventura, CA. NEW ARTICLES IN LIPID SIGNALING Valentine, W.J., et al. "Subtype-specific residues involved in ligand activation of the EDG-family lysophosphatidic acid receptors." J. Biol. Chem. 2008 Mar 3; [Epub ahead of print] (Click here for abstract) Jo, S.K., et al. "Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease." Kindey Int. 2008 Mar 5; [Epub ahead of printe] (Click here for abstract) Huwiler, A., et al. "New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets." Biochem. Pharmacol. 2008 Jan 5; [Epub ahead of print] (Click here for abstract) Ptasynska, M.M., et al. "Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells." Mol. Cancer Res. 2008, 6(3):352-363. (Click here for abstract) LOOKING AT PI3 KINASE SIGNALING PATHWAY…… Miled, N., et al. (2007). Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317:239-242 (Click here for abstract) Lee, J.Y., et al. (2007). PI3K charges ahead. Science 317:206-207 (Click here for abstract) Look to Exalpha’s family of products
Seluanov, A., et al. "Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat." PNAS (2009) 106(46):19352-19357. (click here for abstract) (Submit a publishsed paper or poster referencing Exalpha products and we will send you a $100 credit toward your next Exalpha purchase.) |
||||
|
|
|||||
![]() |
|||||
|
© 2010 Exalpha Biologicals
|
||||