Active Recombinant Sphingosine Kinases

Sphingosine Kinase 1 (Cat. No. X1708E) (pdf) - Sphk1 is widely expressed with highest levels in adult lung, spleen, brain and heart.

Sphingosine Kinase 2 (Cat. No. X1709E) (pdf) - Sphk2 is widely expressed with highest levels in adult kidney, liver and brain

Sphingosine Kinase 2, Long Form (Cat. No. X1840E) (pdf) - Recently discovered splice variant of Sphk2.

Sphingosine Kinase 1a, Mouse (Cat. No. X1850E) (pdf) - Sphk1a enzyme from mouse. Differs from human Sphk1 sequence by the abscence of a valine at position 4.

Active Recombinant Protein Tyrosine Phosphatases

PRL-1 (2-173) (Cat. No. X1657E) (pdf) - Protein tyrosine phosphatase found in the liver. Elevated levels found during major proliferative phase of liver regeneration.

PRL-2 (2-167) (Cat. No. X1658E) (pdf) - Expressed preferentially in skeletal muscle as well as at lower levels in other tissues.

PTP1B (1-132)/PTPN1 (Cat. No. X1659E) (pdf) - PTP which negatively regulates insulin sensitivity by dephosphorylating the insulin receptor.

TC-PTP (2-315)/PTPN2 (Cat. No. X1660E) (pdf) - Dephosphorylates a wide range of phosphoproteins such as p52shc and receptors for EGF, insulin and growth hormones.

MEG-1 (637-926)/PTPN4 (Cat. No. X1661E) (pdf) - Predominantly localized in the nucleus in rat brain and liver but is most highly expressed in testis. Highly conservedbetween species.

MEG-2 (285-593)/PTPN9 (Cat. No. X1662E) (pdf) - A polyphosphoinositide-activated tyrosine phosphatase that may be involved in signaling events regulating phagocytosis and essential antimicrobial funtion in the immune response.

SHP-2 (224-529)/PTPN11 (Cat. NO. X1663E) (pdf) - This PTP relays signals from growth factor receptors to Ras and other effectors.

PEST (2-300)/PTPN12 (Cat. No. X1664E) (pdf) - Plays a central role in regulating WASp (Wiskott-Aldrich syndrome protein) and is absolutely required for WASp contributions to T cell activation.

PTPbeta (1675-1996) (Cat. No. X1665E) (pdf) - Has an important functional role in tumor cell migration and adhesion.

RPTPgamma (801-1147) (Cat. No. X1666E) (pdf) - Receptor-type protein tyrosine phosphatase gamma is expressed in specific regions of the brain and localization of it in the brain changes during brain development.